Tacedinaline - CISMeF

Preferred Label : Tacedinaline;

NCIt synonyms : Acetyldinaline; N-acetyl Dinaline; 4-(Acetylamino)-N-(2-aminophenyl)benzamide;

NCIt related terms : N-acetyldinaline; CI-994;

NCIt definition : An orally bioavailable substituted benzamide derivative with potential antineoplastic activity. Tacedinaline inhibits histone deacetylation, which may result in histone hyperacetylation, followed by the induction of differentiation, the inhibition of cell proliferation, and apoptosis in susceptible tumor cell populations.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of non-small cell lung cancer.;

UNII : UMF554N5FG;

InChIKey : VAZAPHZUAVEOMC-UHFFFAOYSA-N;

CAS number : 112522-64-2;

Molecule name : GOE5549; CI-994; PD 123654;

Chemical formula : C15H15N3O2;

Codes from synonyms : 50123; CDR0000044383; CDR0000044879;

PubMed : 18497959;

Details

Origin ID

C2202;

UMLS CUI

C0217598;

Currated CISMeF NLP mapping
- tacedinaline [MeSH concept]
- tacedinaline [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tacedinaline [MeSH Supplementary Concept]
- tacedinaline [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- CI-994/Gemcitabine [NCIt concept]

Keyword's position in hierarchy(ies) :

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