Preferred Label : Mouse Precursor B Cell Lymphoblastic Lymphoma and Leukemia;
NCIt synonyms : Mouse Precursor B Cell Lymphoblastic Lymphoma Leukemia;
Alternative definition : MMHCC: Precursor B-cell lymphoblastic lymphoma and leukemia. The use of the same name
in the 2 species seems appropriate because of highly similar histologic, cytologic,
phenotypic, and molecular features; Occurrence: Uncommon spontaneous neoplasm of inbred
mice.; MMHCC: Frequent in some GEM and mice infected with acutely transforming MuLV; Necropsy
findings: Splenomegaly, generalized lymphadenopathy, usually with extensive spread
to liver, kidney, and lungs, sometimes to meninges with skull exostoses and hind limb
paralysis; leukemic form in about one third of cases; Cell size: Medium, uniform;
Cytoplasm: Scant; Nuclei: Round or ovoid; chromatin fine; Nucleoli: Variable, often
single, central and prominent but sometimes small and multiple; Mitoses: Numerous;
Pattern: Diffuse, sometimes starry sky because of apoptosis.; MMHCC: Phenotype: Immature B cell, sIg-. B220 CD19 CD43 CD43- Ly6d (ThB) Tdt ;
Molecular: Clonal precursor B cell, IgH G/R, IgK G/G; Characteristic: High grade;
Presumed cell of origin: Bone marrow precursor B-cell lymphoblast; Differential diagnosis:
Histologically and cytologically indistinguishable from most pre-T lymphoblastic lymphoma,
Burkitt lymphoma, and Burkitt-like lymphoma, but CD3- sIg- TdT ; Human counterpart
and commentary.;
Origin ID : C21907;
UMLS CUI : C1524007;
Semantic type(s)
- eo_disease_has_associated_eo_anatomy
- eo_disease_maps_to_human_disease
