Preferred Label : Anti-CD37/DM1 Derivative Antibody-drug Conjugate Debio 1562M;
NCIt synonyms : Anti-CD37/DM1 Derivative ADC Debio 1562M; Anti-CD37 Antibody-drug Conjugate Debio 1562M;
NCIt definition : An antibody-drug conjugate (ADC) composed of naratuximab, a humanized immunoglobulin
G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA)
CD37, covalently linked, via a protease cleavable linker, to a derivative of the maytansinoid
mertansine (DM1), a microtubule disrupting agent, with potential antineoplastic activity.
Upon administration of anti-CD37/DM1 derivative ADC Debio 1562M, the naratuximab moiety
targets and binds to CD37 on tumor B-cells. Upon internalization and linker cleavage
by cathepsin B, the DM1 derivative is released, binds to tubulin and inhibits tubulin
polymerization and microtubule assembly, resulting in G2/M checkpoint arrest and apoptosis
in CD37-expressing tumor cells. CD37, a transmembrane glycoprotein, is overexpressed
in B-cell malignancies.;
Molecule name : Debio 1562M; Debio-1562M;
Origin ID : C219044;
concept_is_in_subset
- has_target
