Preferred Label : Anti-nectin-4 Antibody-drug Conjugate MK-3120;
NCIt synonyms : Anti-nectin-4/TOP1i ADC MK-3120; Anti-nectin-4/TOP1i Antibody-drug Conjugate MK-3120; Anti-nectin-4 ADC MK-3120; Anti-nectin-4 ADC SKB410;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4 (PVRL4)
conjugated, via a hydrophilic linker, to a cytotoxic DNA topoisomerase I inhibitor
(TOP1i), with potential antineoplastic activity. Upon administration of anti-nectin-4
ADC MK-3120, the anti-nectin-4 antibody targets and binds to nectin-4 expressed on
tumor cells. Upon binding, internalization and the release of the TOP1i, the TOP1i
inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting
in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of
nectin-4-expressing tumor cells. MK-3120 is also able to induce a bystander effect
on neighboring cells in the tumor environment. This further inhibits the proliferation
of tumor cells. Nectin-4, a TAA belonging to the nectin family, is overexpressed in
a variety of cancers, but has a restricted distribution in normal tissue.;
Molecule name : MK-3120; SKB-410; SKB 410; MK 3120;
Origin ID : C219034;
concept_is_in_subset
- has_target
