Preferred Label : Anti-CLDN6/Anti-CD3 Bispecific Antibody BGB-B455;
NCIt synonyms : Anti-CLDN6/CD3 T-cell Engaging Bispecific Antibody BGB-B455; Anti-CLDN6/CD3 Bispecific Antibody BGB-B455; CLDN6/CD3 Bispecific T-cell Engager BGB-B455; CLDN6 x CD3 Bispecific Antibody BGB-B455;
NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) claudin 6
(CLDN6; CLDN-6) and the T-cell surface antigen CD3, with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CLDN6/anti-CD3 bispecific
antibody BGB-B455 targets and binds to both CLDN6 expressed on tumor cells and CD3
expressed on T-cells. This activates and redirects cytotoxic T-lymphocytes (CTLs)
to CLDN6-expressing tumor cells, which leads to enhanced CTL-mediated killing of CLDN6-expressing
tumor cells. CLDN6, a tight-junction protein and embryonic antigen, is overexpressed
on a variety of tumor cells but is not or minimally expressed on normal, healthy adult
cells.;
Molecule name : BGB-B455; BGB B455;
Origin ID : C218840;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
