Preferred Label : VRP-encapsulated saRNA Encoding IL-12 VLPONC-01;
NCIt synonyms : VRP-IL-12 VLPONC-01; IL-12 saRNA VLPONC-01; Virus Replicon Particle-encapsulated Self-amplifying RNA Encoding IL-12 VLPONC-01;
NCIt definition : A formulation consisting of virus replicon particles (VRPs) encapsulating self-amplifying
RNA (saRNA) encoding human interleukin-12 (IL-12), with potential immunomodulatory
and antineoplastic activities. Upon intratumoral injection of VRP-encapsulated saRNA
encoding IL-12 VLPONC-01, the saRNA is translated by the cellular protein translation
machinery to produce IL-12, which is secreted into the local tumor microenvironment
(TME). The secretion of IL-12 activates the immune system by promoting the secretion
of interferon-gamma (IFN-g), activating natural killer cells (NKs), and inducing cytotoxic
T-lymphocyte (CTL) responses, which may enhance immune-mediated destruction of tumor
cells and decrease tumor cell proliferation. saRNA yields a higher amount of protein
expression than mRNA.;
Molecule name : VLPONC-01; VLPONC 01;
Origin ID : C218432;
concept_is_in_subset
