Preferred Label : Pneumococcal 21-Valent Conjugate Vaccine;
NCIt synonyms : PCV 21 Vaccine; PCV 21;
NCIt definition : A pneumococcal conjugate vaccine containing 21 different strains of the bacterium
Streptococcus pneumoniae, that is used for the prevention of pneumococcal disease.
The pneumococcal 21-valent conjugate vaccine contains capsular antigen polysaccharides
derived from the S. pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15B
(de-O-acetylated prior to conjugation), 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31,
33F, and 35B that are individually conjugated to a nontoxic diphtheria cross-reactive
material 197 (CRM197) carrier protein to create 21 individual conjugates. Upon intramuscular
vaccination, pneumococcal 21-valent conjugate vaccine induces active immunization
against these 21 different serotypes of S. pneumoniae and protects against pneumococcal
disease. As the de-O-acetylated polysaccharide from serotype 15B has a molecular structure
similar to the polysaccharide from serotype 15C, this polysaccharide also induces
an immune response and kills S. pneumoniae serotype 15C.;
Drug name : CAPVAXIVE;
Origin ID : C217737;
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