Preferred Label : Anti-GPRC5D/MMAE Antibody-drug Conjugate AZD0305;
NCIt synonyms : Anti-GPRC5D/MMAE ADC AZD0305; Anti-GPRC5D ADC AZD0305; Anti-GPRC5D Antibody-drug Conjugate AZD0305;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the human G-protein coupled receptor family C group 5 member D (GPRC5D) conjugated
to the auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl
auristatin E (MMAE), with potential antineoplastic activity. Upon administration of
anti-GPRC5D/MMAE ADC AZD0305, the anti-GPRC5D antibody moiety selectively binds to
tumor cells expressing GPRC5D. Upon binding and internalization, MMAE binds to tubulin
and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis
in GPRC5D-expressing tumor cells. In addition, AZD0305 induces an antibody-dependent
cell-mediated cytotoxicity (ADCC) against GPRC5D-expressing tumor cells, thereby further
killing the tumor cells. GPRC5D is overexpressed on certain tumors, such as multiple
myeloma, while minimally expressed on normal, healthy cells, and plays a key role
in tumor cell proliferation.;
Molecule name : AZD-0305; AZD 0305;
Origin ID : C217729;
concept_is_in_subset
- has_target
