Preferred Label : miR-126 Inhibitor miRisten;
NCIt synonyms : CpG(D19)-Anti-miR-126; ODN-based CpG-Anti-miRNA-126; miRisten; MicroRNA-126 Inhibitor miRisten; CpG-linked Anti-Mir-126 Oligonucleotide;
NCIt definition : An inhibitor of microRNA miR-126 (MiR-126-3p) composed of an anti-miR-126 RNA antisense
oligodeoxynucleotide (ODN) linked to a cytosine-phosphate-guanine (CpG) DNA ODN, with
potential antineoplastic activity. Upon administration, miR-126 inhibitor miRisten
targets, binds to and inhibits miR-126 in leukemia stem cells (LSCs) and endothelial
cells (ECs), thereby preventing transcription and promoting elimination of miR-126
from the circulation. As miR-126 plays a key role in the self-renewal and persistence
of cancer-causing LSCs, this may eliminate the LSCs. In addition, the depletion of
miR-126 downregulates BCL-2 and disrupts mitochondrial function and metabolism, leading
to increased levels of reactive oxygen species (ROS) and the induction of apoptosis
in LSCs. miR-126, expressed in normal hematopoietic stem and progenitor cells (HSPC),
maintains self-renewal capacity and renewal. Aberrantly increased in LSCs, miR-126
supports homeostasis, quiescence, and activity of LSCs, and enhances mitochondrial
metabolism and mitochondrial dynamics in LSCs. CpG DNA ODN, a ligand for scavenger
receptors (SRs), is highly expressed on the surface of LSCs and endothelial cells,
and allows for efficient cell delivery of anti-miR-126 ODN.;
Molecule name : Oligodeoxynucleotide Anti-miR-126 Inhibitor miRisten;
Origin ID : C217532;
chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
