Invasive Adenocarcinoma of the Mouse Prostate Gland - CISMeF
Invasive Adenocarcinoma of the Mouse Prostate GlandNCIt concept
Preferred Label : Invasive Adenocarcinoma of the Mouse Prostate Gland;
Alternative definition : MMHCC: Well differentiated in humans generally restricted to transition zone (clear
cell) carcinomas, often associated with BPH nodules. As such anatomic associations
have not been observed or do not occur in mice and carcinomas morphologically similar
to human well differentiated prostate carcinomas have not been observed, well differentiated
adenocarcinoma (conceptually and morphologically similar to human term) should not
be used as a mouse designation at the current time.; MMHCC: Invasive carcinoma is the penetration of malignant epithelial cells (that demonstrates
unequivocal glandular proliferation) through the basement membrane into the surrounding
stroma (Degree of differentiation will be defined based on the extent of glandular
proliferation).;