Preferred Label : Autologous dNPM1 Peptides-specific HLA-A*02:01-restricted TCR T-lymphocytes MB-dNPM1-TCR.1;
NCIt synonyms : Autologous dNPM1-TCR Transduced T-cells MB-dNPM1-TCR.1; Autologous dNPM1-specific HLA-A*02:01-restricted TCR T-cells MB-dNPM1-TCR.1; Autologous Anti-dNPM1 TCR T-cells MB-dNPM1-TCR.1;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified using
a lentiviral vector to express a T-cell receptor (TCR) specific for certain dNPM1
peptides restricted to human leukocyte antigen (HLA)-A*02:01, with potential antineoplastic
activity. Upon isolation, transduction, expansion ex vivo and re-introduction into
the patient, the autologous dNPM1 peptides-specific HLA-A*02:01-restricted TCR T-lymphocytes
MB-dNPM1-TCR.1 target and bind to the HLA/dNPM1 peptide complex on tumor cells, which
leads to the elimination of tumor cells expressing dNPM1. Mutated forms of NPM1 (nucleophosmin
1), a multifunctional chaperone protein, are found on certain tumor cells, including
leukemic myeloid cells.;
Molecule name : MB-dNPM1-TCR.1;
Origin ID : C217333;
concept_is_in_subset
