Preferred Label : Anti-MuSK Agonistic Monoclonal Antibody ARGX-119;
NCIt synonyms : Anti-MuSK Agonist Monoclonal Antibody ARGX-119; Anti-MuSK Monoclonal Antibody ARGX-119;
NCIt definition : A humanized agonistic monoclonal antibody directed against the antigen muscle, skeletal
receptor tyrosine-protein kinase (MuSK; muscle-specific kinase), that may potentially
stabilize and improve the function of the neuromuscular junction (NMJ). Upon administration,
anti-MuSK agonistic monoclonal antibody ARGX-119 specifically targets and activates
MuSK, thereby activating MuSK-mediated signaling pathways. This may restore NMJ formation,
stability and signaling, thereby stabilizing and improving the function of the NMJ.
MuSK is a transmembrane protein expressed on skeletal muscle cell membrane that plays
an important role in the formation and maintenance of the NMJ.;
Molecule name : ARGX 119; ARGX-119;
Origin ID : C217324;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
