Preferred Label : High Grade Mouse Prostatic Intraepithelial Neoplasia;
Alternative definition : MMHCC: High grade based on marked nuclear atypia, including macronucleoli, marked
enlargement with hyperchromasia and irregular nuclear contours, abundant mitoses/apoptosis,
luminal comedo necrosis.; MMHCC: mPIN which has shown documented progression to invasive cancer.; MMHCC: Qualifier of local vs. extensive/diffuse can be added, similar to that described
above for atypical hyperplasia. Focal as one to several foci, less than 50% of glands
involved. Extensive/diffuse indicating involvement of greater than or equal to 50%
of glands.; MMHCC: In human, HGPIN occurs in previously normal prostate, so epithelial proliferation
occurs within preexisting basement membrane bound glands and ducts. In transgenic
mouse, creation of apparently increased glandular spaces compared to wild type mice
is not necessarily indicative of invasive carcinoma. If such a lesion occurs uniformly
throughout the prostate, for example, with lobular expansion by connecting large and
small duct profiles (with similar cytologic atypia), and a symmetric lower power architecture,
this should likely be considered an in situ process (e.g., images LPBTag12T5-7689DLP(10x);
TRAMP538(10x); LPBTag12T7f-7874DLP(10x)). This concept is particularly evident when
architecturally distinct foci of unequivocal stromal or periprostatic fat invasion
(of small crowded glands, single cells, or nests of cells) occur against this more
uniform symmetric lobular expansion HGPIN background.;
Origin ID : C21730;
UMLS CUI : C1522068;
Semantic type(s)
- eo_disease_has_associated_eo_anatomy
- eo_disease_maps_to_human_disease
