Preferred Label : Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland;
Alternative definition : MMHCC: Mouse PIN (mPIN) is defined histologically as proliferation of atypical epithelial
cells within pre-existing glands and ducts and is still confined by the basement membrane.; MMHCC: Conceptually, distinguished from epithelial hyperplasia with atypia by unequivocally
documented association with invasive carcinoma, such that the terms PIN/HGPIN have
similar meaning/implications as in human. Thus far, such invasion has been observed
primarily in SV40 early region/large T antigen containing transgenes (and possibly
the BK5-IGF1 mouse). In these models, the in situ lesions CAN be distinguished morphologically
from mice showing epithelial proliferation with atypia. T antigen models show much
more pronounced nuclear atypia, including greater nuclear enlargement and pleomorphism,
coarser chromatin, irregular nuclear contours, and higher mitotic and apoptotic rates.; MMHCC: Epithelial proliferation with nuclear atypia, without invasion. Proliferation
typically manifest as nuclear stratification. Atypia manifest as progressively severe
nuclear enlargement, chromatin abnormalities, and enlarged nucleoli.;
Origin ID : C21728;
UMLS CUI : C1522511;
Semantic type(s)
- eo_disease_has_associated_eo_anatomy
- eo_disease_maps_to_human_disease
