Preferred Label : Anti-GARP Monoclonal Antibody PBA-0111;
NCIt synonyms : Anti-glycoprotein A Repetitions Predominant Monoclonal Antibody PBA-0111;
NCIt definition : An afucosylated human monoclonal antibody directed against the transforming growth
factor beta (TGF-beta) activator glycoprotein A repetitions predominant (GARP; leucine-rich
repeat-containing protein 32; LRRC32), with potential immunomodulating and antineoplastic
activities. Upon administration, anti-GARP monoclonal antibody PBA-0111 selectively
targets and binds to GARP. This specifically blocks the GARP-mediated release of the
cytokine TGF-beta 1 (TGF-b1), thereby relieving the immunosuppression caused by TGF-b1,
inhibiting immunosuppressive regulatory T-cells (Tregs) in the tumor microenvironment
(TME), and reversing the immunosuppressive nature in TME. This improves cytotoxic
T-cell-mediated anti-tumor immune responses and results in the elimination of tumor
cells. GARP, a transmembrane protein highly expressed on activated, immunosuppressive
Tregs in the TME, is essential for the expression of TGF-b1 on the cell surface of
activated Tregs; it plays an important role in regulation of the immune cell function
and the immunosuppressive nature of Tregs. TGF-b1 stimulates stromal cell proliferation,
neovascularization, cancer cell metastasis, and inhibits immune cell infiltration.;
Molecule name : PBA-0111; PBA 0111;
Origin ID : C217174;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
