Preferred Label : Paclitaxel-Eluting Film PTM-101;
NCIt synonyms : Paclitaxel Absorbable Film Formulation PTM-101;
NCIt definition : A biodegradable film and multilayer polymeric formulation of paclitaxel, with potential
antineoplastic activity. Upon placement of the paclitaxel-eluting film PTM-101 directly
to the peritumoral area, the drug-eluting layer provides sustained-release of paclitaxel,
while the backbone layer ensures the unidirectional release of paclitaxel. Once the
paclitaxel is released, it binds to tubulin inside tumor cells and inhibits the disassembly-assembly
dynamics of microtubules, resulting in tumor cell cycle arrest and tumor cell death.
The release of paclitaxel at the site of tumor may allow for the delivery of higher
doses to cancer cells while minimizing systemic exposure and toxicities.;
Molecule name : PTM 101; PTM-101;
Origin ID : C216981;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
