Preferred Label : Cereblon E3 Ubiquitin Ligase Modulating Drug BMS-986449;
NCIt synonyms : CelMoD BMS-986449; Cereblon E3 Ubiquitin Ligase Modulating Agent BMS-986449; Cereblon Modulator BMS-986449; Cereblon Modulating Drug BMS-986449; IKZF2/IKZF4 Degrader BMS-986449;
NCIt definition : A modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin
ligase), with potential immunomodulating and antineoplastic activities. Upon administration,
BMS-986449 specifically targets and binds to cereblon (CRBN), thereby affecting the
ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination.
This induces proteasome-mediated degradation of certain transcription factors, some
of which are transcriptional repressors in regulatory T-cells (Tregs), such as Ikaros
family zinc finger protein 2 (IKZF2; zinc finger protein Helios), and IKZF4 (zinc
finger protein Eos). This reprograms Tregs and leads to the modulation of the immune
system, including activation of T-lymphocytes, and results in a T-cell-mediated anti-tumor
immune response.;
Molecule name : BMS 986449; BMS-986449;
Origin ID : C216970;
concept_is_in_subset
- has_target
