Preferred Label : Anti-CD228/MMAE Antibody-drug Conjugate PF-08046031;
NCIt synonyms : Anti-CD228 ADC PF-08046031; Anti-CD228 Antibody-drug Conjugate PF-08046031; Anti-melanotransferrin ADC PF-08046031; Anti-CD228-MMAE ADC PF-08046031; Anti-CD228/MMAE ADC PF-08046031;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human immunoglobulin G1 (IgG1) antibody
targeting the cell surface antigen cluster of differentiation 228 (CD228; melanotransferrin;
MFI2; MELTF; p97; MTf) that is conjugated, via a cleavable linker, to the microtubule-disrupting
cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.
Upon administration, the antibody moiety of anti-CD228/MMAE ADC PF-08046031 targets
and binds to CD228 on the surface of tumor cells. Following internalization of PF-08046031
and transport to lysosomes, MMAE is released, binds to tubulin, and inhibits microtubule
polymerization. This results in microtubule disruption and apoptosis in CD228-expressing
tumor cells. CD228, a cell-surfaced, glycosylphosphatidylinoitol (GPI)-anchored glycoprotein,
belongs to the transferrin family of iron-binding proteins. CD228 expression is elevated
in multiple solid tumors but has limited expression in normal tissues.;
Molecule name : PF 08046031; PF-08046031;
Origin ID : C216967;
concept_is_in_subset
- has_target
