Alternative definition : MMHCC: The HAN has been proven to be pre-neoplastic (premalignant) by serial transplantation
into the gland-cleared fat pad of syngeneic mice. The serial transplantation proves
that the HAN is immortal; MMHCC: The hyperplastic outgrowths of HAN transplants undergo a high rate of malignant
transformation proving their risk of undergoing malignant transformation. The HAN
will not grow or become malignant if it is transplanted into the subcutaneous tissue; MMHCC: The HAN (hyperplastic alveolar nodule) is the prototypical Lobuloalveolar lesion.
The HAN is a focal area with closely packed acini with slightly atypical nuclei; MMHCC: A focus of residual alveoli that persist in the mouse mammary gland following
hormone stimulation;