" /> Low Grade Mouse MIN - CISMeF





Preferred Label : Low Grade Mouse MIN;

NCIt synonyms : Low Grade MIN;

Alternative definition : MMHCC: A focal atypical, non-invasive epithelial lesion with minimal atypia and low malignant potential. Atypical hyperplasia, DIN and certain grades of DCIS are considered human homologs. Focal increase of epithelium that contains cells with atypical nuclei. Limited to focal lesions with mild to moderate cytological atypia. When transplanted, the foci grow in gland cleared mammary fat pads but not in the subcutaneous tissue. Low grade lesions seldom undergo malignant transformation and do not metastasize. Mammary Intraepithelial Neoplasia (MIN) has been proposed by the Annapolis Pathology Panel as the preferred term. It is considered the mouse counterpart or synonym for Atypical Hyperplasia, DIN in the human breast. Some pathologists believe that these proliferations are premalignant. Nuclear atypia corresponds to a nuclear score of one in the Elston-Ellis grading system.;

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04/05/2025


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