Preferred Label : Anti-GARP Chimeric Antigen Receptor-T Cells;
NCIt synonyms : Anti-GARP CAR T-cells; Anti-GARP CAR-T Cells; Anti-GARP CAR T Cells;
NCIt definition : A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR)
targeting the tumor-associated antigen (TAA) and transforming growth factor beta (TGFbeta)
activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing
protein 32; LRRC32), with potential antineoplastic activity. Upon administration,
anti-GARP CAR-T cells recognize, bind to and kill GARP-expressing tumor cells. GARP
is widely expressed by a variety of human cancer cells compared with normal, healthy
cells.;
Origin ID : C216252;
concept_is_in_subset
- has_target
