Preferred Label : Anti-IL-18BP Monoclonal Antibody GS-0321;
NCIt synonyms : Anti-IL18BP Monoclonal Antibody GS-0321;
NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against interleukin-18-binding
protein (IL18BP; IL-18BP), with potential immunostimulatory and antineoplastic activities.
Upon administration, anti-IL-18BP monoclonal antibody GS-0321 targets and binds to
IL-18BP. This results in the release of the pro-inflammatory cytokine IL-18 from pre-formed
IL-18:IL-18BP complex. IL-18 binds to and activates the IL-18 receptor, which activates
T-cells and natural killer (NK) cells and induces the secretion of interferon-gamma
(IFNg). This potentiates the immune response against tumor cells. IL-18BP acts as
a decoy receptor of IL-18 and prevents the activation of IL-18 receptor in the tumor
microenvironment (TME).;
Molecule name : GS 0321; COM 503; COM-503; GS-0321;
Origin ID : C216196;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
