Preferred Label : Anti-GPRC5D Monoclonal Antibody SAR446523;
NCIt definition : A Fc-engineered immunoglobulin G1 (IgG1) monoclonal antibody directed against the
tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member
D (GPRC5D), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-GPRC5D monoclonal antibody SAR446523 targets and binds to GPRC5D expressed on
certain tumor cells. This results in an antibody-dependent cell-mediated cytotoxicity
(ADCC) against GPRC5D-expressing tumor cells, thereby killing the cancer cells. GPRC5D
is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed
on normal, healthy cells, and plays a key role in tumor cell proliferation.;
Molecule name : SAR 446523; SAR-446523;
Origin ID : C216128;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
