Preferred Label : Anti-ILT4 Monoclonal Antibody CHS-1000;
NCIt synonyms : Anti-LILRB2 Monoclonal Antibody CHS-1000;
NCIt definition : A Fc-modified humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against
the inhibitory immune checkpoint receptor immunoglobulin-like transcript 4 (LILRB2;
ILT4; leukocyte immunoglobulin-like receptor subfamily B member 2; lymphocyte immunoglobulin-like
receptor 2; LIR2; monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d),
with potential immunomodulating and antineoplastic activities. Upon administration,
anti-ILT4 monoclonal antibody CHS-1000 targets and binds to LILRB2. This prevents
the binding of LILRB2 ligands HLA-A and HLA-G to their receptor and prevents LILRB2-mediated
signaling. This abrogates the immunosuppressive activities of LILRB2 in the tumor
microenvironment (TME), promotes re-polarization of suppressive myeloid cells to a
pro-inflammatory phenotype, enhances activation of dendritic cells (DCs) and T cells,
and increases pro-inflammatory cytokine secretion leading to tumor cell death. ILILRB2,
a transmembrane protein and inhibitory member of the immunoglobulin-like transcript
(ILT) family of proteins, is expressed primarily by myeloid cells, including monocytes,
macrophages, DCs and granulocytes, and in certain tumors. It plays a key role in tumor
immune evasion.;
Molecule name : CHS-1000; CHS 1000;
Origin ID : C216086;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
