Preferred Label : Anti-CD20 Bispecific Antibody DR-0201;
NCIt synonyms : MCE DR-0201; Bispecific Myeloid Cell Engager DR-0201;
NCIt definition : A bispecific monoclonal antibody that targets the human tumor-associated antigen (TAA)
CD20, with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CD20 bispecific antibody DR-0201 targets and binds to CD20 on B-cell surface.
This results in CD20-mediated signaling blockade and may induce phagocytosis of CD20-overexpressing
cells by tissue-resident and trafficking myeloid cells, such as macrophages. This
results in a depletion of pathogenic B-cells. CD20 is overexpressed by certain cancer
cell types and in various autoimmune diseases.;
Molecule name : DR 0201; DR-0201;
Origin ID : C216082;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
