Proteasome Inhibitor

Preferred Label : Proteasome Inhibitor;

NCIt definition : Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis.;

Alternative definition : NCI-GLOSS: A drug that blocks the action of proteasomes. A proteasome is a large protein complex that helps destroy other cellular proteins when they are no longer needed. Proteasome inhibitors are being studied in the treatment of cancer.;

ChEBI ID : CHEBI:52726;

Codes from synonyms : CDR0000393541;

Details

Origin ID

C2160;

UMLS CUI

C1443643;

Automatic exact mappings (from CISMeF team)
- Proteasome inhibitor (disposition) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Product containing proteasome inhibitor (product) [SNOMED CT concept]
- Substance with proteasome inhibitor mechanism of action (substance) [SNOMED CT concept]
- proteasome inhibitors [MeSH concept]
- proteasome inhibitors [MeSH Descriptor]
Manual BTNT mappings - CISMeF
- Proteasome inhibitors [ATC Code]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing proteasome inhibitor (product) [SNOMED CT concept]
- Substance with proteasome inhibitor mechanism of action (substance) [SNOMED CT concept]
- proteasome inhibitors [MeSH concept]
- proteasome inhibitors [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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