Preferred Label : Anti-nectin-4 Antibody-drug Conjugate IPH4502;
NCIt synonyms : Anti-nectin-4 ADC IPH4502; Anti-nectin-4/Exatecan ADC IPH4502;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
Fc-competent monoclonal antibody directed against the cell surface adhesion molecule
and tumor-associated antigen (TAA) nectin-4 (PVRL4) conjugated, via a hydrophilic
cleavable linker, to the camptothecin analog and topoisomerase 1 inhibitor exatecan,
with potential antineoplastic activity. Upon administration of anti-nectin-4 ADC IPH4502,
the anti-nectin-4 antibody targets and binds to nectin-4 expressed on tumor cells.
Upon binding, internalization and linker cleavage, exatecan is released. Exatecan
inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting
in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of
nectin-4-expressing tumor cells. IPH4502 is also able to induce a bystander effect
on neighboring cells in the tumor environment. This further inhibits the proliferation
of tumor cells. In addition, the Fc-competent monoclonal antibody of IPH4502 may induce
both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity
(CDC) against nectin-4-expressing tumor cells. Nectin-4, a TAA belonging to the nectin
family, is overexpressed in a variety of cancers, but has a restricted distribution
in normal tissue.;
Molecule name : IPH 4502; IPH-4502;
Origin ID : C215837;
concept_is_in_subset
- has_target
