Preferred Label : 26S Proteasome-Associated UCH Interacting Protein 1;
Obsolete resource : true;
NCIt synonyms : Three Prime Repair Exonuclease 2 Isoform UIP1; UIP1; TREX2; XQ28ORF;
NCIt definition : Alternative splicing of the TREX2 gene results in five transcript variants. 26S Proteasome-Associated
UCH Interacting Protein 1 results from use of a different open reading frame, producing
a protein structurally unrelated to the other isoforms of Three Prime Repair Exonuclease
2 also encoded by the same gene. This protein interacts with ubiquitin C-terminal
hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The
physiological role of Ubiquitin C-terminal Hydrolases (UCH) is to hydrolyze C-terminal
esters and amides of ubiquitin and to generate free monomeric ubiquitin from ubiquitin
proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble
polyubiquitin chains. (From PubMed and NCI);
Concept status : Retired_Concept;
GenBank Accession Number : NM_007205;
Origin ID : C21560;
OMIM relation
- Semantic type(s)
