Preferred Label : Antibody/PNE-based Biologic Agent ABBV-461;
NCIt synonyms : Switch Biologic Molecule ABBV-461; Anti-TAA Antibody Fragment/PNE Biologic Molecule ABBV-461; TAA-specific CLBR001 Adapter Molecule ABBV-461;
NCIt definition : A biologic agent composed of an antibody fragment targeting an as of yet unidentified
tumor-associated antigen (TAA) that is linked to a 14 aa peptide epitope, or alpha-peptide
neo-epitope (PNE), recognizable by autologous alpha-PNE switchable CAR-T cells CLBR001,
that may be used to activate CLBR001. Upon administration of the antibody-based biologic
agent ABBV-461, and upon co-administration of CLBR001, the antibody moiety targets
and binds to tumor cells expressing the TAA. In turn, the PNE part of ABBV-461 binds
to the binding domain of CLBR001, thereby activating CLBR001. This induces selective
toxicity in and causes lysis of the TAA-expressing tumor cells to which ABBV-461 is
bound.;
Molecule name : ABBV 461; ABBV-461;
Origin ID : C215159;
concept_is_in_subset
