Preferred Label : Anti-STEAP1 Antibody-drug Conjugate ADRX-0405;
NCIt synonyms : Anti-STEAP1/TOP1i ADC ADRX-0405; Anti-STEAP1 ADC ADRX-0405; Anti-STEAP1/Topoisomerase I Inhibitor ADC ADRX-0405;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody targeting the tumor-associated antigen (TAA) six transmembrane
epithelial antigen of the prostate 1 (STEAP1) conjugated, through a protease-cleavable
linker, to a topoisomerase 1 (TOP1) inhibitor payload, with potential antineoplastic
activity. Upon administration of anti-STEAP1 ADC ADRX-0405, the antibody moiety targets
and binds to STEAP1 expressed on tumor cells. Following receptor internalization and
linker cleavage, the TOP1 inhibitor targets and inhibits the activity of DNA topoisomerase
1, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor
cell apoptosis of STEAP1-overexpressing tumor cells. STEAP1 is overexpressed in a
variety of cancers, including prostate cancer, while its expression in normal healthy
tissue is limited.;
Molecule name : ADRX 0405; ADRX-0405;
Origin ID : C215119;
concept_is_in_subset
- has_target
