Preferred Label : KAT6 Inhibitor MEN2312;
NCIt synonyms : KAT6A/B Inhibitor MEN2312; KAT6A/KAT6B Inhibitor MEN2312;
NCIt definition : An orally bioavailable inhibitor of MYST histone acetyltransferase (HAT) KAT6, with
potential antineoplastic activity. Upon oral administration, KAT6 inhibitor MEN2312
targets and binds to KAT6, and inhibits the acetylation of histones and other nonhistone
substrates. This may disrupt gene expression and inhibit the proliferation of tumors
that overexpress KAT6. KAT6A (MOZ; MYST3) and KAT6B (MORF; MOZ2; MYST4), commonly
amplified genes in solid tumors, play key roles in cell cycle regulation and in tumorigenesis.;
Molecule name : MEN-2312; MEN 2312;
Origin ID : C215101;
concept_is_in_subset
- has_target
