Preferred Label : Anti-HLA-G Monoclonal Antibody UCB4594;
NCIt definition : An afucosylated humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting HLA-G
histocompatibility antigen, class I, G (human leukocyte antigen G; HLA-G), with potential
immune checkpoint inhibiting, immunomodulating and antineoplastic activities. Upon
administration, the anti-HLA-G monoclonal antibody UCB4594 targets and binds to HLA-G,
thereby preventing the binding of HLA-G to its inhibitory receptors immunoglobin-like
transcript (ILT) 2 and ILT4 on a variety of immune cells, such as natural killer cells
(NKs), T- and B-lymphocytes, and dendritic cells (DCs). This may prevent HLA-G-mediated
immune suppression, thereby activating both innate and adaptive immune responses.
This may activate anti-tumor immune responses. In addition, UCB4594 induces direct
NK cell-mediated killing of tumor cells, complement dependent lysis and antibody-dependent
cellular phagocytosis (ADCP). HLA-G, an immune checkpoint normally expressed at the
maternal-fetal interface, is expressed across multiple tumor types and plays a key
role in cancer immune evasion.;
Molecule name : UCB-4594; UCB 4594;
Origin ID : C215081;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
