Preferred Label : Anti-CD24 Monoclonal Antibody KH-801;
NCIt definition : A Fc-engineered humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the
cell surface protein cluster of differentiation 24 (CD24), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration, anti-CD24 monoclonal
antibody KH-801 selectively targets and binds to CD24 expressed on tumor cells, thereby
blocking the interaction of CD24 with sialic acid-binding Ig-like lectin 10 (Siglec-10)
expressed on innate immune cells including tumor-associated macrophages (TAMs) in
the tumor microenvironment (TME). This prevents CD24/Siglec-10-mediated signaling
and abrogates the CD24/Siglec-10-mediated inhibition of macrophage-mediated phagocytosis
of tumor cells. This results in macrophage-dependent tumor cell phagocytosis, repolarization
from the immunosuppressive M2 subtype macrophages to the anti-tumor M1 subtype in
the TME, and the abrogation of the immunosuppressive TME. This causes immune activation
and T-cell infiltration. In addition, KH-801 further induces antibody-dependent cellular
cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) through its
Fc-mediated immune effector function. CD24, a glycophosphatidylinositol (GPI)-anchored,
highly glycosylated cell adhesion protein, is overexpressed on the surface of a variety
of cancer cells. Expression of CD24, and its interaction with Siglec-10, protects
cancer cells from phagocytosis, thereby allowing cancer cells to proliferate.;
Molecule name : KH-801; KH 801;
Origin ID : C215078;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
