Preferred Label : Anti-B7-H6/Anti-CD3 Bispecific Antibody TGI-6;
NCIt synonyms : B7-H6 x CD3 Bispecific Antibody TGI-6; Anti-B7-H6/CD3 Bispecific Antibody TGI-6;
NCIt definition : A bispecific antibody directed against both natural cytotoxicity triggering receptor
3 ligand 1 (NCR3LG1; B7-H6) and T-cell surface antigen CD3, with potential immunostimulating
and antineoplastic activities. Upon administration, anti-B7-H6/anti-CD3 bispecific
antibody TGI-6 targets and binds to both B7-H6 on tumor cells and CD3 on T-cells.
This results in the cross-linking of B7-H6-expressing tumor cells and T-cells, redirects
cytotoxic T-lymphocytes (CTLs) to B7-H6-expressing tumor cells, which leads to the
CTL-mediated cell death of B7-H6-expressing tumor cells. B7-H6, a member of the B7
family of immune modulators, is expressed in a variety of tumor cell types while minimally
or not expressed in normal tissues. It is a specific ligand for the natural killer
(NK) cell activating receptor NKp30, and may modulate NK cell function in certain
cancers.;
Molecule name : TGI 6; TGI-6;
Origin ID : C215076;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
