Preferred Label : SCD1 Inhibitor MTI-301;
NCIt synonyms : Stearoyl-CoA Desaturase 1 Inhibitor MTI-301; 2-{[4-(2-Chlorophenoxy)piperidine-1-carbonyl]amino}-N-methylpyridine-4-carboxamide;
NCIt definition : An orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor, with potential
antineoplastic and immunomodulating activities. Upon oral administration, SCD1 inhibitor
MTI-301 targets, binds to the saturated fatty acid (SFA) pocket and inhibits the activity
of SCD1, thereby preventing the oxidation of SFAs to monounsaturated fatty acids (MUFAs).
This prevents fatty acid synthesis in cancer cells and the fatty acid-mediated promotion
of tumor growth, metastasis and drug resistance. This leads to endoplasmic reticulum
(ER) stress and induces apoptotic cell death. Inhibition of SCD1 may also activate
the adaptive immune response and may promote T-cell-mediated tumor immune responses.
In addition, MTI-301 may sensitize cancers to immune checkpoint inhibitors. SCD1,
an enzyme converting SFAs to MUFAs, promotes fatty acid synthesis in cancer cells
and is upregulated in certain types of cancer. SCD1 plays a key role in tumor immunosuppression.;
Molecule name : MTI-301; MTI 301; SSI 4; SSI-4;
Origin ID : C215015;
concept_is_in_subset
- has_target
