Preferred Label : Anti-CD33 Antibody-drug Conjugate BL-M11D1;
NCIt synonyms : Gemtuzumab/Ed-04 ADC BL-M11D1; Anti-CD33 ADC BL-M11D1;
NCIt definition : An antibody-drug conjugate (ADC) composed of gemtuzumab, an immunoglobulin G4 (IgG4)
monoclonal antibody directed against the CD33 antigen, conjugated, via a cathepsin
B-cleavable linker, to the camptothecin derivative and topoisomerase 1 inhibitor Ed-04,
with potential antineoplastic activity. Upon administration of anti-CD33 ADC BL-M11D1,
gemtuzumab specifically targets and binds to the cell surface antigen CD33 expressed
on myeloid leukemia cells. Upon binding, internalization and linker cleavage, Ed-04
is released and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and apoptosis in tumor cells that express CD33.
Gemtuzumab may also induce an antibody-dependent cellular cytotoxicity (ADCC) against
CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic
stem cells and myeloid leukemia cells.;
Molecule name : BL-M11D1; BL M11D1;
Origin ID : C214994;
concept_is_in_subset
- has_target
