Preferred Label : Indium In 111-XYIMSR-01;
NCIt synonyms : 111In-XYIMSR-01; [111In]XYIMSR-01;
NCIt definition : A radioconjugate consisting of XYIMSR-01, a bivalent low molecular weight ligand targeting
two separate sites on carbonic anhydrase IX (CAIX), conjugated with the bifunctional,
macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled
with indium In 111 (111In), with potential imaging activity during single photon emission
computed tomography (SPECT). Upon administration of indium In 111-XYIMSR-01, XYIMSR-01
targets and binds to CAIX-expressing tumor cells, followed by internalization and
retention of the radioisotope. This allows for imaging of CAIX-expressing tumor cells
upon SPECT. CAIX is overexpressed in various tumors and plays a key role in intra-
and extracellular pH regulation, cancer cell progression, survival, migration and
invasion.;
Origin ID : C214910;
concept_is_in_subset
