Preferred Label : Anti-GPC3 T Cell-engaging Antibody AZD9793;
NCIt synonyms : T-cell Engager AZD9793; CD8/TCR-based GPC3-targeting T-cell Engaging Antibody AZD9793; TCE AZD9793; Anti-GPC3/Anti-CD3/Anti-CD8 Trispecific Antibody AZD9793; TCE Antibody AZD9793; Anti-Glypican-3 T Cell-engaging Antibody AZD9793; T Cell-engaging Antibody AZD9793;
NCIt definition : A T-cell engaging (TCE) asymmetric trispecific immunoglobulin G1 (IgG1) antibody targeting
the tumor-associated antigen (TAA) glypican-3 (GPC3; GPC-3) and the T-cell surface
antigens CD3 and CD8, with potential immunostimulating and antineoplastic activities.
Upon administration, anti-GPC3 TCE antibody AZD9793 targets and binds to GPC3 expressed
on tumor cells and to CD3 and CD8 antigens on CD8-positive T-lymphocytes. This activates
and redirects CTLs to GPC3-expressing tumor cells, which results in the CTL-mediated
death of GPC3-expressing tumor cells. GPC3, a heparan sulfate proteoglycan and a member
of the glypican family, is overexpressed on certain tumor cell types while minimally
expressed in normal, healthy cells. GPC3 plays an important role in tumor cell proliferation
in various tumor cell types.;
Molecule name : AZD 9793; AZD-9793;
Origin ID : C214841;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
