Preferred Label : Allogeneic Anti-EGFR CAR/HLA-A*02-gated Inhibitory Receptor-expressing T-lymphocytes
A2B395;
NCIt synonyms : Allogeneic Anti-EGFR CAR/HLA-A*02-gated Inhibitory Receptor-expressing T Cells A2B395; Allogeneic Anti-EGFR CAR/HLA-A*02-gated Inhibitory Receptor-expressing T-cells A2B395; Allogeneic Anti-EGFR Logic-gated Tmod CAR-T Cells A2B395;
NCIt definition : A preparation of allogeneic T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the epidermal growth factor receptor
(EGFR; HER1; ErbB1), and a leukocyte immunoglobulin-like receptor 1 (LIR-1)-based
inhibitory receptor specific for human leukocyte antigen (HLA)-A*02 (HLA-A*02), with
potential immunomodulating and antineoplastic activities. Upon administration, the
allogeneic anti-EGFR CAR/HLA-A*02-gated inhibitory receptor-expressing T-lymphocytes
A2B395 target and bind to EGFR-expressing tumor cells, thereby killing EGFR-expressing
tumor cells that have loss of heterozygosity (LOH) for HLA-A*02 protein. The inhibitory
receptor specific for HLA-A*02 acts as a self-regulated safety switch that blocks
the killing of HLA-A*02-positive EGFR-expressing normal, healthy cells. This may also
protect the normal, healthy cells from graft versus host disease (GvHD) resulting
from the administration of the allogeneic T-cells. HLA-A*02 is expressed on normal
cells but not on tumor cells due to LOH. EGFR, overexpressed by a variety of cancers,
plays a key role in tumor cell proliferation and survival.;
Origin ID : C214776;
concept_is_in_subset
- has_target
