Preferred Label : Isotope-release Cytotoxicity Assay;
Alternative definition : CDISC: An assay that is used to quantify cytotoxic effector cell activity (e.g., cytotoxic
T cell (CTL) or natural killer (NK) cell) by measuring target cell lysis. The process
involves bathing and labeling the target cells with a radioactive isotope (e.g. Chromium
51 or Indium-111) or fluorescent molecule. The target cells are then mixed with the
effector cells (CTL or NK). The killing of the labeled target cells leads to the release
of the radioactive isotope into the supernatant after cell lysis. Accumulation of
the radioactive isotope is quantified and measured in the supernatant which indicates
effector cell-mediated cytolysis.;
Origin ID : C214705;
concept_is_in_subset
