Preferred Label : Amrecibart;
NCIt synonyms : Anti-factor XI Antibody REGN9933; Anti-factor XI Monoclonal Antibody REGN9933; Anti-FXI Monoclonal Antibody REGN9933;
NCIt definition : An anti-factor XI (FXI) antibody, with potential anti-thrombotic activity. Upon administration,
amrecibart targets and binds to the apple 2 (A2) domain of FXI and activated FXI (FXIa),
thereby preventing the intrinsic pathway-triggered FXI activation. This prolongs the
activated partial thromboplastin time (aPTT) and reduces platelet and fibrin accumulation.
This results in the inhibition of contact activation-initiated blood coagulation and
prevents thrombus formation. FXI contributes to thrombotic disease while playing a
limited role in normal hemostasis. Activation of FXI is essential for thrombus growth
and stabilization.;
UNII : ZDR9VW2WMN;
CAS number : 3008610-20-3;
Molecule name : REGN-9933; REGN 9933;
Origin ID : C214499;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
