Preferred Label : Cenvacibart;
NCIt synonyms : Anti-factor XI Antibody REGN7508; Anti-factor XI Monoclonal Antibody REGN7508; Anti-FXI Monoclonal Antibody REGN7508;
NCIt definition : An immunoglobulin G4 (igG4), human anti-factor XI (FXI) antibody, with potential anti-thrombotic
activity. Upon administration, cenvacibart targets and binds to the catalytic domain
of FXI, thereby preventing the activation of FXI (FXIa). The abrogation of FXI activation
prolongs the activated partial thromboplastin time (aPTT) and reduces platelet and
fibrin accumulation. This results in the inhibition of contact activation-initiated
blood coagulation and prevents thrombus formation. FXI contributes to thrombotic disease
while playing a limited role in normal hemostasis. Activation of FXI is essential
for thrombus growth and stabilization.;
UNII : 6NM5PD4YTH;
CAS number : 3008610-21-4;
Molecule name : REGN 7508; REGN-7508;
Origin ID : C214498;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
