Preferred Label : OMA1 Activator BTM-3566;
NCIt definition : An orally bioavailable activator of the mitochondrial protease OMA1, with potential
antineoplastic activity. Upon oral administration, OMA1 activator BTM-3566 activates
OMA1. This leads to OMA1-dependent cleavage of DAP3-binding cell death enhancer 1
(DELE1) and mitochondrial dynamin-like GTPase OPA1, mitochondrial fragmentation, and
activation of the eIF2alpha-kinase heme-regulated inhibitor (HRI), and induces cyclic
AMP-dependent transcription factor ATF-4-mediated integrated stress response (ISR)
and hyperactivates mitochondrial ISR, which result in apoptosis. OMA1 plays a key
role in the activation of the ISR pathway in response to hypoxia, amino acid deprivation,
and accumulation of misfolded proteins. While ISR promotes the adaptation of tumor
cells to hypoxic stress, prolonged activation of ISR induces apoptosis.;
Molecule name : BTM-3566; BTM 3566;
Origin ID : C213887;
concept_is_in_subset
