Preferred Label : Anti-HLA-A*02/NY-ESO-1 Bispecific T-cell Engager DS-2243a;
NCIt synonyms : Bispecific TCE DS-2243a; Anti-NY-ESO-1 T-cell Engaging Bispecific Antibody DS-2243a; Bispecific T-cell Engager Anti-HLA-A*02/NY-ESO-1 DS-2243a;
NCIt definition : A T-cell engaging bispecific antibody directed against the tumor-associated antigen
(TAA) NY-ESO-1 complexed with human leukocyte antigen (HLA)-A*02 (HLA-A*02) and an
antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-HLA-A*02/NY-ESO-1 bispecific T-cell engager
DS-2243a targets and binds to an antigen found on cytotoxic T-lymphocytes (CTLs) and
NY-ESO-1 presented by HLA-A*02 expressed on tumor cells. This activates and redirects
CTLs to NY-ESO-1-expressing tumor cells, which results in the CTL-mediated cell death
of NY-ESO-1-expressing tumor cells. NY-ESO-1, a cell surface protein expressed in
normal fetal and adult testes, is upregulated in a variety of tumor cell types as
a HLA-A*02/NY-ESO-1 complex.;
Molecule name : DS-2243a; DS 2243a; DS-2243; DS 2243;
Origin ID : C213676;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
