Preferred Label : DHX9 Inhibitor ATX-559;
NCIt synonyms : Helicase DHX9 Inhibitor ATX-559; RNA Helicase A Inhibitor ATX-559;
NCIt definition : An orally bioavailable inhibitor of the protein RNA helicase A (DHX9; DDX9; RHA),
with potential antineoplastic activity. Upon oral administration, DHX9 inhibitor ATX-559
targets, binds to and inhibits DHX9. This may cause genomic instability and may lead
to DNA replication stress and DNA damage, and may induce apoptosis in certain vulnerable
cancer cells. DHX9, a multi-functional RNA helicase, is involved in the maintenance
of genomic stability by resolving DNA/RNA secondary structures that may lead to DNA
replication stress and DNA damage in certain molecularly defined cancers.;
Molecule name : ATX 559; ATX-559;
Origin ID : C213562;
concept_is_in_subset
- has_target
