Preferred Label : CDC7 Kinase Inhibitor LY3143921;
NCIt synonyms : LY-3143921 Free Base;
NCIt related terms : LY-3143921;
NCIt definition : An orally bioavailable inhibitor of cell division cycle 7 (CDC7) kinase, with potential
antineoplastic activity. Upon administration, CDC7 kinase inhibitor LY3143921 targets,
binds to and inhibits the activity of CDC7, which may result in the inhibition of
DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition
of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine
kinase CDC7 plays a key role in DNA replication by binding to and phosphorylating
serine (Ser)-40 and 53 of MCM2 (minichromosome maintenance complex component 2), which
is required for the initiation of DNA replication. Although expressed at low levels
in healthy, normal cells, CDC7 is expressed at much higher levels in cancer cells.;
UNII : PZU987ZDK2;
CAS number : 1627696-51-8;
Molecule name : LY-3143921; LY 3143921;
Origin ID : C213500;
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