" /> CIC/FOXO4 Fusion Gene - CISMeF





Preferred Label : CIC/FOXO4 Fusion Gene;

NCIt synonyms : CIC-FOXO4 Fusion Gene; Capicua Transcriptional Repressor/Forkhead Box O4 Fusion Gene; Capicua Transcriptional Repressor-Forkhead Box O4 Fusion Gene; CIC::FOXO4 Fusion Gene; CIC-FOXO4 Gene Rearrangement;

NCIt definition : A fusion gene that results from a chromosomal translocation t(X;19)(q13;q13) that fuses exon 19 or 20 of the CIC gene in-frame with exon 2 of the FOXO4 gene. This fusion is associated with CIC-rearranged sarcoma.;

NCIt note : CIC/FOXO4 fusion transcripts were characterized using RNAseq, RT-PCR/direct sequencing and FISH; the putative fusion protein has not been observed.; Transcripts for the reciprocal FOXO4/CIC fusion were not detected.;

PubMed : 25007147; 25321332;

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31/07/2025


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