Preferred Label : EWSR1/SMARCA5 Fusion Protein;
NCIt synonyms : EWSR1::SMARCA5 Fusion Protein; EWSR1-SMARCA5 Fusion Protein; EWS RNA Binding Protein 1-SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator
of Chromatin Subfamily A Member 5 Fusion Protein;
NCIt definition : A fusion protein encoded by the EWSR1/SMARCA5 fusion gene. This protein is comprised
of the N-terminal transactivational and serine-tyrosine-glutamine-glycine-rich (SYGG)
domains of the RNA-binding protein EWS followed by the SWI/SNF-related matrix-associated
actin-dependent regulator of chromatin subfamily A member 5 protein, including the
following five conserved domains: 1) the SNF2 helicase N-terminal ATPase domain, including
the DEAH box, 2) the SrmB helicase C-terminal domain, 3) the C-terminal DNA and nucleosome
binding IWSI/Hand domain, 4) the DNA binding Slide domain, and 5) two DNA-binding
SANT domains.;
PubMed : 21113140;
Origin ID : C213496;
concept_is_in_subset
- gene_encodes_gene_product
- related_to_genetic_biomarker
