Preferred Label : Clostridioides difficile Toxin B-binding proteins/Endolysin Combination LMN-201;
NCIt synonyms : C. difficile TcdB-binding proteins/Endolysin Combination LMN-201; C. difficile TcdB-binding proteins/Endolysin Combination Agent LMN-201;
NCIt definition : An orally bioavailable combination agent composed of a whole, dried, non-viable biomass
of spirulina (Arthrospira platensis) grown from four separate strains expressing three
toxin-binding proteins targeting Clostridioides difficile toxin B (TcdB) and a phage-derived
endolysin, with potential antibacterial activity. Upon oral administration of C. difficile
TcdB-binding proteins/endolysin combination LMN-201, the C. difficile TcdB-binding
proteins bind to distinct epitopes of the TcdB, thereby preventing the binding of
the toxin to target host cells. TcdB is one of two exotoxins responsible for the symptoms
of Clostridium difficile infections. In addition, the phage-derived endolysin degrades
the cell wall of C. difficile, resulting in bacterial cell lysis. Altogether, this
may prevent or treat C. difficile infection.;
Molecule name : LMN 201; LMN-201;
Origin ID : C213489;
concept_is_in_subset
