Mesencephalic Astrocyte-Derived Neurotrophic Factor

Preferred Label : Mesencephalic Astrocyte-Derived Neurotrophic Factor;

NCIt synonyms : Protein ARMET; ARMET Protein; Arginine-Rich Mutated in Early Stage Tumors; ARMET; Arginine-Rich Protein;

NCIt definition : Mesencephalic astrocyte-derived neurotrophic factor (179 aa, 20 kDa) is encoded by the human MANF gene. This protein is involved in both the function and survival of dopaminergic neurons.;

NCIt note : The product of the MANF gene was originally thought to have an arginine-rich sequence in the amino terminal region, however; this genetic information is in the 5'-untranslated region of the mRNA. The mutation that is involved in tumor formation occurs in the initiation codon of the gene (previously numbered as codon 50) and results from either deletion of the codon or a point mutation (AUG to AGG). (Entrez Gene and SwissProt);

Details

Origin ID

C21337;

UMLS CUI

C0390113;

Currated CISMeF NLP mapping
- MANF protein, human [MeSH concept]
- MANF protein, human [MeSH Supplementary Concept]
- Mesencephalic astrocyte-derived neurotrophic factor [ORDO Gene]
OMIM relation
- Mesencephalic astrocyte-derived neurotrophic factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MANF protein, human [MeSH Supplementary Concept]
- MANF protein, human [MeSH concept]
- Mesencephalic astrocyte-derived neurotrophic factor [ORDO Gene]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- MANF Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Nerve Cell Survival [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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